The Hyperlipidemia Treatment Market witnessed robust growth in 2021 and is expected to continue growing rapidly due to the increasing target population and growing awareness of the danger of cardiovascular diseases caused by persistent hyperlipidemia. However, the market could be negatively impacted by the adverse effects of antihyperlipidemic medications. Hyperlipidemia refers to inherited and acquired illnesses in which the body's lipid levels are abnormally high. The growing elderly and geriatric population is expected to drive market growth during the projected period. However, patients with hyperlipidemia have a wide range of responses to treatment therapy, with many being intolerant to statins and nonresponsive to them. Anti-hyperlipidemic drugs are often associated with various gastrointestinal adverse effects that act as a barrier to market growth.
The North America market is expected to account for the largest revenue share over the forecast period due to the introduction of new treatment options, increased healthcare expenditure, and availability of treatment options. The Asia Pacific market is expected to register significant revenue growth due to the considerable increase in geriatric population and the existence of generic manufacturers in this area. Recent innovations in the market include the development of a small interfering RNA molecule called Inclisiran, which uses the body's natural technique of preventing RNA production of PCSK-9 mRNA to inhibit PCSK-9 synthesis in liver cells. Additionally, targeted ANGPTL3 inhibitors such as Anti-ANGPTL3 antibodies, Antisense Oligonucleotide (ASOs), and small interfering RNAs (siRNAs) have been discovered and are currently being tested in clinical trials.
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Major companies in Hyperlipidemia Treatment Market:
- AstraZeneca
- Sun Pharmaceutical Industries Ltd.
- Pfizer Inc.
- Johnson & Johnson Private limited
- Reckitt Benckiser Group plc.
- Novartis AG
- Reddy’s Laboratories Ltd
- GlaxoSmithKline plc.
- Bristol-Myers Squibb Company
- Eli Lilly and Company
- Daiichi Sankyo company, Limited
- Amgen Inc.
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Driving Factors in Hyperlipidemia Treatment Market:
The hyperlipidemia treatment market is being driven by several factors. Firstly, there is an increasing prevalence of hyperlipidemia, with millions of people over the age of 20 having high cholesterol levels. Additionally, the growing elderly and geriatric population is expected to drive market growth, as well as the addition of more diseases with high cholesterol and triglyceride levels to the statin target group. The introduction of new treatment options and rising awareness for this disease has also led the market to grow. However, there are also several factors that could negatively impact market growth, such as the wide range of responses to treatment therapy and various gastrointestinal adverse effects associated with anti-hyperlipidemic drugs. Nonetheless, the rise in the number of research and development activities of pharmaceuticals for targeted treatment of hyperlipidemia is fueling market expansion, along with the development of novel treatments such as human monoclonal antibodies and small interfering RNAs. The market also presents opportunities for education and awareness campaigns to increase public knowledge about this disease.
Restraint in Hyperlipidemia Treatment Market:
One of the main restraints in the hyperlipidemia treatment market is the wide range of responses that patients have to treatment therapy, with many being intolerant or non-responsive to statins. This reduces the number of individuals using statins as a treatment medication, which can hinder market growth. Additionally, anti-hyperlipidemic drugs are often associated with various gastrointestinal adverse effects, which can act as a barrier to market expansion. Lack of trained professionals for treatment and lack of awareness among people about this disease are other factors that could stifle market growth.
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Notable Innovations in Hyperlipidemia Treatment Market:
- Small interfering RNA (siRNA) molecules: Inclisiran is a siRNA molecule that uses the body's natural technique of preventing RNA production of PCSK-9 mRNA. It inhibits PCSK-9 synthesis in liver cells by using RNA silencing mechanism (RISC). Inclisiran was found in Phase 2 trials to lower LDL cholesterol whether administered with or without a statin. This drug is given as a subcutaneous injection every six months on average.
- Antisense Oligonucleotide (ASOs): ASOs are being developed as targeted ANGPTL3 inhibitors and are currently being tested in phase I–III clinical trials. ANGPTL3 inhibitors were seen to improve lipid profiles, even in treatment-resistant human homozygous familial hyperlipidemia.
- Human monoclonal antibodies: Evolocumab and alirocumab are human monoclonal antibodies that block the action of proprotein convertase subtilisin-kexin type 9 enzyme (PCSK-9). PCSK-9 is a protein that binds to hepatic LDL receptors and binds to LDL cholesterol.
These innovations have the potential to offer patients new treatment options that could potentially be more effective than current therapies, leading to improved patient outcomes. They also offer opportunities for pharmaceutical companies to differentiate themselves in the hyperlipidemia treatment market and drive market growth.
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